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Comparative Analysis of Conventional Papanicolaou Tests and a Fluid-Based Thin-Layer Method
Context.—A fluid-based, direct-to-vial method of thinlayer gynecologic cytology (ThinPrep Pap Test) is reported to be more effective than the conventional Papanicolaou
test in the detection of squamous intraepithelial lesions. Objective.—This retrospective analysis evaluated the validity of the findings on the thin-layer method using case material at a large independent laboratory and represented a comparison of performance of both methods over an identical period.
Methods.—Data for conventional and ThinPrep tests were compared for 2 periods. Period 1 included 1 421 080 conventional and 56 835 ThinPrep specimens, and period 2 included 564 270 conventional and 109 784 ThinPrep specimens. Squamous intraepithelial lesions were used to determine detection of disease. These 2 sets of data were
also analyzed to eliminate effects of any selection bias toward ThinPrep for high-risk patients.
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Report of a ThinPrep test case in a 17-year-old woman
ThinPrep Pap test of endocervical adenocarcinoma with lymph node metastasis: Report of a case in a 17-year-old woman
David G. Wagner, Joseph Weisensel, Mark J. Mentrikoski, Sharon D. Leo, Thomas A. Bonfiglio and Rana S. Hoda
Article first published online: 25 NOV 2009 | DOI: 10.1002/dc.21257
Diagnostic Cytopathology Volume 38, Issue 9, pages 633–638, September 2010
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